美國Thermo Fisher Dharmacon www.dharmacon.com
Thermo Scientific Dharmacon® 創(chuàng)立于1995年，是世界領(lǐng)先的siRNA產(chǎn)品供應(yīng)商和RNAi技術(shù)服務(wù)商，其憑借三大技術(shù)和六類產(chǎn)品，建立了全新的基因沉默標(biāo)準(zhǔn)。最新統(tǒng)計(jì)顯示，全球頂尖雜志Nature系列期刊文章中使用Dharmacon產(chǎn)品的數(shù)目已高達(dá)1200多篇，這一數(shù)據(jù)遙遙領(lǐng)先于RNAi領(lǐng)域內(nèi)的其它品牌，奠定了其目前在RNAi研究領(lǐng)域無可替代的領(lǐng)軍者地位。
三大技術(shù)：
SMARTselection™ 技術(shù)-----確保了siRNA的功能性和特異性； 
SMARTpool® 技術(shù)------不用任何驗(yàn)證即可確保靶基因表達(dá)水平沉默至少75%； 
ON-TARGETplus™ -----顯著降低基因沉默中的脫靶效應(yīng)，效率高達(dá)90%以上。 
六類產(chǎn)品：
Accell™ siRNA------該產(chǎn)品是RNAi研究領(lǐng)域具革命性的一項(xiàng)創(chuàng)舉，它無需任何傳統(tǒng)介質(zhì)（如轉(zhuǎn)染試劑、病毒載體和電轉(zhuǎn)）即可將siRNA高效遞送進(jìn)入任何類型細(xì)胞； 
MiRIDIAN® microRNA Mimics & hairpin Inhibitors------設(shè)計(jì)先進(jìn)，調(diào)節(jié)功能異常強(qiáng)大，實(shí)驗(yàn)結(jié)果高度可重復(fù)。 
siGENOME™ siRNA-----四大組合，打造了全球最全面、最可靠的siRNA基因沉默平臺； 
DharmaFECT™ 轉(zhuǎn)染試劑------五種選擇，可滿足siRNA對眾多細(xì)胞的高效超低毒轉(zhuǎn)染； 
siRNA對照產(chǎn)品-----多個(gè)產(chǎn)品，提供業(yè)內(nèi)最全面可靠的siRNA對照產(chǎn)品菜單，為成功研究基因沉默創(chuàng)造了良好條件； 
siRNA文庫------多達(dá)30條信號通路/基因家族的siRNA文庫可以對整條信號通路或者整個(gè)基因家族的功能進(jìn)行批量標(biāo)準(zhǔn)化的研究。 

We are part of Thermo Fisher Scientific, the world leader in serving science. Thermo Fisher Scientific enables customers to make the world healthier, cleaner and safer by providing analytical instruments, equipment, reagents and consumables, software and services for research, analysis, discovery and diagnostics. With annual sales of more than $9 billion, Thermo Fisher Scientific has 30,000 employees and serves more than 350,000 customers in pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies as well as environmental, industrial quality and process control settings.
 
Dharmacon History 
Dharmacon Research, Inc. was founded in 1995 by Stephen Scaringe to develop and commercialize a new technology for RNA oligonucleotide synthesis. The original Dharmacon focus and vision was to develop 2'-ACE RNA technology as the standard for RNA synthesis and to advance RNA oligo-dependent applications and technologies. When RNA interference (RNAi) emerged in the late 1990's, Dharmacon was poised to provide RNAi-related products to the multitude of academic and industry researchers. Dharmacon has become an important resource for those investigating the mechanisms of siRNA (small interfering RNA)-induced gene knockdown and applying the specificity and potency of RNAi to human biotherapeutics. Dharmacon's expertise in bioinformatics, RNA biology, and synthesis chemistry has allowed it to develop a complete line of products for the RNAi researcher, including SMARTselection™ designed siRNA and SMARTpool® siRNAs carrying a guarantee of at least 75% silencing of any specific gene, the siGENOME® siRNA collection targeting all unique genes in the human genome, and Dharmacon siRNA Libraries targeting gene families or genes involved in specific cell pathways; siRNA libraries are also available in Reverse Transfection Format.
In November of 2002, Dharmacon Research, Inc. officially changed its name to Dharmacon, Inc., to reflect the increasing capabilities and future growth potential of the company, as it had advanced beyond research and development and into whole solutions for RNA oligo-dependent applications and technologies. In March of 2004, Dharmacon became a wholly owned subsidiary of Fisher Scientific International, Inc. In November of 2006, Fisher Scientific International, Inc. merged with Thermo Electron Corporation to become Thermo Fisher Scientific.